Diltiazem Inhibits Coronary Spasm via Inhibition of Cav1.2Phosphorylation and Protein Kinase C Activation in a Mouse Model of Coronary Spastic Angina
نویسندگان
چکیده
Calcium antagonists are used for coronary spastic angina (CSA) treatment. We previously identified a phospholipase C (PLC) -δ1 gene variant that results in enhanced PLC activity patients with CSA and developed animal model by generating vascular smooth muscle cell-specific human PLC-δ1 overexpression (PLC-TG) mice. In this study, we investigated the molecular mechanism of using PLC-TG mice inhibitory effect calcium antagonist, diltiazem hydrochloride (DL).
منابع مشابه
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ژورنال
عنوان ژورنال: International Heart Journal
سال: 2021
ISSN: ['1349-3299', '1349-2365']
DOI: https://doi.org/10.1536/ihj.20-366